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Low Carb Chicken Casserole Recipe is a quick and easy Keto meal that you can bake any day of the week. It is a perfect chicken for meal prep because it reheats beautifully, is so moist and delicious, and can be paired with so much.

This Low Carb Chicken Casserole Recipe is decadent. It is creamy, cheesy and is very satisfying. It has tons of protein and good fat and will keep you full and satisfied.
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What We Love About This Recipe
A keto diet or low carb diet is where your body produces ketones in the liver to be used as energy. This tasty and flavorful chicken is perfect for this diet plan but is also a family favorite. If you do not follow this diet, but if you want to learn more, check this KETO link.
- 55 Minute Meal: Only 15 minutes of prep and the rest is cooking time.
- Easy Ingredients: All found in pantry or fridge, so it is super easy.
- Family Friendly: With the creamy, cheesy flavor it is a hit for all ages.
- Adaptable: Can make it with so many wonderful side dishes, it never gets boring.
- Makes Great Leftovers: Have this chicken on salad the next day for lunch or serve on a low carb bun as a sandwich.
Ingredient Notes for Keto Chicken Breast Recipes
- Chicken: Boneless, skinless chicken breast or chicken thighs.
- Sour Cream: Rich, creamy and full fat.
- Parmesan Cheese: Grate your own or buy pre-grated.
- Mozzarella Cheese: Gives that satisfying cheese pull.
- Xanthan Gum: This is a gluten-free thickening agent.
- Italian Seasoning: Adds a real punch of flavor with garlic, rosemary and oregano.

Equipment Needed
- Baking Dish
- Measuring Cup
- Measuring Spoons
- Mixing Bowls
How to Make Low Carb Chicken Casserole Recipe
These are the basic steps for making cheesy chicken casserole. Please refer to the recipe card below for more detailed instructions.
STEP 1: PREP
First, preheat your oven to 350 degrees and spray your baking dish with a nonstick spray.

STEP 2: COMBINE
Then in a bowl, mix together the sour cream, Parmesan cheese, xanthan gum, Italian seasoning, garlic powder and salt and pepper to taste until well combined.

STEP 3: CHICKEN
Next, place the tenderloins in baking dish, and spread the sour cream mixture over them. Then sprinkle with the mozzarella cheese and remaining parmesan cheese and bake for 40 minutes.
STEP 4: GARNISH
Lastly, sprinkle the keto chicken casserole with fresh parsley and serve.
Prep and Storage Tips for Low Carb Chicken Casserole Recipe
HOW TO MAKE THIS RECIPE AHEAD OF TIME
Really, this recipe comes together very quickly, however you can make the sour cream mixture ahead of time and then when you are ready to bake, simply follow the recipe directions below.
HOW TO STORE THIS RECIPE
Chicken can last in your fridge between three and four days in an airtight container or well wrapped.
HOW TO FREEZE THIS RECIPE
According to the USDA, cooked poultry casseroles or pieces covered with broth or gravy will last up to 6 months in the freezer when stored properly in a freezer bag or airtight container.
HOW TO REHEAT THIS RECIPE
Thaw the chicken in the fridge overnight and reheat in the oven at 350 degrees until warmed through.
Frequently Asked Questions with Low Carb Casserole with Chicken
Really, it is easy to make this recipe low calorie. Try using low calorie or fat free versions of the sour cream and cheeses.
Of course, use a boneless skinless chicken thigh in place of the chicken tenderloins in this easy recipe.
Indeed, great for a party or large gathering, simply increase the ingredients on the recipe card below and follow the same directions.
It is important to cook chicken to the correct doneness, however no one likes dry chicken. Therefore, the best trick is to get a good meat thermometer, and when inserted into the thickest part the chicken should reach an internal temperature of 165˚F.

Expert Tips for Making This Recipe
- Add Different Cheeses: Experiment with different cheese to make the meal your own, provolone, Gouda etc.
- Short cut tip: No need to cut and debone your chicken breasts, buy them prepared in tenderloins already.
- Variation tip: Diced tomato, is a nice addition to this dish.
- Alternate cooking method tip: Feel free to cook this chicken in the instant pot on high pressure for 10 minutes and then quick release. Air Fry for 6 minutes per side at 400 degrees.
What to Serve with Low Carb Chicken Casserole Recipe?
- Green Beans
- Cauliflower Rice
- Spinach

Low Carb Chicken Casserole Recipe
Equipment
- Baking Dish
- Measuring Cup
- Measuring Spoons
- Mixing Bowls
Ingredients
- 1 ½ pounds Boneless skinless chicken breast tenderloins
- ⅔ Cup Sour cream
- ½ Cup Parmesan cheese, grated
- 1 Cup Mozzarella cheese shredded
- ¼ teaspoon Xanthan gum
- 2 teaspoons Italian seasoning
- 1 teaspoon Garlic powder
- Salt and pepper to taste
- Chopped parsley for garnish
Instructions
- Preheat the oven to 350 degrees.
- In a bowl, mix together the sour cream, ¼ cup of the Parmesan cheese, xanthan gum, Italian seasoning, garlic powder and salt and pepper to taste until well combined.
- Place the tenderloins in a well greased baking dish, and spread the sour cream mixture over them.
- Sprinkle the mozzarella cheese and remaining Parmesan cheese on top.
- Bake for 40 minutes.
- Sprinkle with chopped parsley before serving.
Expert Tips
- Add Different Cheeses: Experiment with different cheese to make the meal your own, provolone, Gouda etc.
- Short cut tip: No need to cut and debone your chicken breasts, buy them prepared in tenderloins already.
- Variation tip: Diced tomato, is a nice addition to this dish.
- Alternate cooking method tip: Feel free to cook this chicken in the instant pot on high pressure for 10 minutes and then quick release. Air Fry for 6 minutes per side at 400 degrees.
Estimated Nutritional Information
The nutritional information provided are estimates. To learn more about how I calculate this information go to www.itisakeeper.com/about-its-a-keeper/privacy-disclosure-policies/
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This cheesy chicken casserole was good! I just loved the way the flavors came together. I served it with a side dish of carrots for a complete weeknight meal that was nice and easy to make. Thanks for the excellent recipe.